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| 英文名称 | Anti-HER2 Polyclonal Antibody |
| 别名 | erbB-2 isoform 2;HER2 receptor;Erbb2 protein;CerbB2;c erb B2;C erbB 2;C-erbB2;CD340;Erb B2;erbb2;HER 2;Her-2;HER 2/neu;HER2;Her2/neu;Herstatin;MLN 19;MLN19;NEU;NEU Proto Oncogene;Neuro Glioblastoma Derived Oncogene Homolog;NGL;p185 ErbB2;p185erbB2;Receptor Protein Tyrosine Kinase ErbB2 Precursor;Receptor tyrosine protein kinase erbB 2;TKR1;Tyrosine kinase type cell surface receptor HER2;v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian);ERBB2_HUMAN;Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;Proto-oncogene Neu;Proto-oncogene c-ErbB-2. |
| 宿主 | Rabbit |
| 稀释比例 | ELISA 1:500-1000. IHC-P 1:100-500. IHC-F.1:100-500. ICC 1:100. IF 1:100-500. |
| Gene ID | 2064 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04626 |
| 蛋白分子量 | 135kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm Nucleus |
| 免疫原 | KLH conjugated synthetic peptide derived from human HER2 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | ELISAIFICCIHC-FIHC-P |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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