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产品简介
| 英文名称 | Anti-CDK6 Polyclonal Antibody |
| 别名 | CDK 6;CDK6;Cell division protein kinase 6;Crk 2;Crk2;Cyclin dependent kinase 6;Cyclin-dependent kinase 6;MGC59692;p40;PLSTIRE;Serine/threonine-protein kinase PLSTIRE;STQTL11;CDK6_HUMAN;PLSTIRE;Serine/threonine protein kinase PLSTIRE. |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 1ug/test. IF 1:100-500. |
| Gene ID | 1021 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q00534 |
| 蛋白分子量 | 37kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell projection Cytoplasm Nucleus centrosome cytoskeleton microtubule organizing center ruffle |
| 免疫原 | KLH conjugated synthetic peptide derived from human CDK6 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanCowHorseDogRatMouse |
| 应用 | WBIFFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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