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产品简介
| 英文名称 | Anti-WNT5A Polyclonal Antibody |
| 别名 | wingless-related MMTV integration site 5A;hWNT 5A;hWNT5A;Protein Wnt 5a;Protein Wnt5a;Wingless type MMTV integration site family member 5A;Wnt-5a;WNT 5A protein precursor;WNT5A protein precursor;WNT5A_HUMAN |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 7474 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P41221 |
| 蛋白分子量 | 35kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Extracellular matrix Secreted |
| 免疫原 | KLH conjugated synthetic peptide derived from human WNT5A |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanCowRabbitPigRatMouse |
| 应用 | WBIFIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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