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产品简介
| 英文名称 | Anti-P53(wt-p53) Polyclonal Antibody |
| 别名 | Widespread p53;Wtp53;Antigen NY-CO-13;Cellular tumor antigen p53;Cys 51 Stop;HGNC11998;LFS1;p53;p53 Cellular Tumor Antigen;p53 Tumor Suppressor;Phosphoprotein p53;TP53;Transformation related protein 53;TRP53;Tumor protein p53;Tumour Protein p53;P53_HUMAN;TP53. |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 1μg /test. ICC 1:100. IF 1:100-500. |
| Gene ID | 7157 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04637 |
| 蛋白分子量 | 23/30/34/38/44kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Endoplasmic reticulum Mitochondrion matrix Nucleus PML body |
| 免疫原 | KLH conjugated synthetic peptide derived from human P53 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPigHorseRabbitSheepDogRatMouse |
| 应用 | WBIFICCFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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