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产品简介
| 英文名称 | Anti-PARP Polyclonal Antibody |
| 别名 | ADP ribosyltransferase (NAD+;poly (ADP ribose) polymerase);ADP ribosyltransferase NAD+;ADPRT 1;ADPRT;ADPRT1;msPARP;NAD(+) ADP ribosyltransferase 1;pADPRT 1;pADPRT1;PARP 1;PARP1;Poly (ADP ribose) polymerase 1;poly (ADP ribose) polymerase family, member 1;Poly adenosine diphosphate ADP ribose polymerase;Poly ADP ribose polymerase 1;Poly ADP ribose polymerase family member 1;Poly ADP ribose synthetase 1;poly(ADP ribose) synthetase;poly(ADP ribosyl)transferase;Poly[ADP ribose] synthetase 1;PPOL;sPARP 1;sPARP1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 0.2μg/Test. IF 1:100-500. |
| Gene ID | 142 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P09874 |
| 蛋白分子量 | 116kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein |
| 免疫原 | KLH conjugated synthetic peptide derived from human PARP |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanCowDogRatMouse |
| 应用 | WBIFFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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