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产品简介
| 英文名称 | Anti-DKK1 Polyclonal Antibody |
| 别名 | Dickkopf 1;Dickkopf 1 like;Dickkopf homolog 1;Dickkopf related protein 1;DKK 1;hDkk 1;hDkk1;DKK-1;SK |
| 宿主 | Rabbit |
| 稀释比例 | ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 22943 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O94907 |
| 蛋白分子量 | 29kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Secreted |
| 免疫原 | KLH conjugated synthetic peptide derived from human DKK1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanDogRatMouse |
| 应用 | ELISAIFIHC-FIHC-P |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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