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产品简介
| 英文名称 | Anti-TAP2 Polyclonal Antibody |
| 别名 | ABC18;ABCB3;Peptide supply factor 2;Peptide transporter PSF2;Peptide transporter TAP2;PSF2;RING 11;TAP 2;Transporter 2 ATP binding cassette sub family B |
| 宿主 | Rabbit |
| 稀释比例 | ELISA 1:500-1000. Flow-Cyt 1μg/Test. |
| Gene ID | 6891 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | C9J069 |
| 蛋白分子量 | 75kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane |
| 免疫原 | KLH conjugated synthetic peptide derived from human TAP2 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPigCowHorseRabbitDogRatMouse |
| 应用 | ELISAFlow-Cyt |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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