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产品简介
| 英文名称 | Anti-CD163 Polyclonal Antibody |
| 别名 | Scavenger receptor cysteine-rich type 1 protein M130;CD 163;CD163 antigen;CD163 molecule;Hemoglobin Scavenger Receptor;M130;M130 antigen precursor;Macrophage associated antigen;MM130 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 3ug/Test. ICC 1:100-500. IF 1:100-500. |
| Gene ID | 9332 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q86VB7 |
| 蛋白分子量 | 125/121kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Secreted |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD163 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPigHorseDogRatMouse |
| 应用 | WBIFICCFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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