Anti-phospho-CSF1R (Tyr923) Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-phospho-CSF1R (Tyr923) Polyclonal Antibody
别名	MCSF Receptor;C FMS;CD 115;CD115;CD115 antigen;CFMS;Colony stimulating factor 1 receptor;Colony stimulating factor I receptor;CSF 1 R;CSF 1R;CSF-1 receptor;CSF-1-R;CSF1 R;CSF1R;CSF1R_HUMAN;CSFR;FIM 2;FIM2;FMS;FMS proto oncogene
宿主	Rabbit
稀释比例	WB 1:500-2000. ELISA 1:500-1000. Flow-Cyt 1μg /test.
Gene ID	1436
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P07333
蛋白分子量	108kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Cell membrane
免疫原	KLH conjugated Synthesised phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 923
亚型	IgG
纯化方法	Affinity purification
背景资料	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
克隆类型	Polyclonal Antibody
交叉反应	HumanMouse
应用	WBFlow-CytELISA
规格	50ul100ul