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产品简介
| 英文名称 | Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody |
| 别名 | beta Catenin (phospho S33/37);beta Catenin (phospho Ser33/37);p-beta Catenin (S33/37);p-beta Catenin (Ser33/37);p-beta Catenin (phospho S33/37);beta-catenin;beta catenin;CTNNB1;CHBCAT;CTNNB1;CTNNB;PRO2286;Cadherin associated protein |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 0.2μg /test. ICC 1:100-500. IF 1:100-500. |
| Gene ID | 1499 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P35222 |
| 蛋白分子量 | 85kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus Cell membrane |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Ser33/37 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanpigRabbitChickenRatMouse |
| 应用 | WBIFICCFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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