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| 英文名称 | Anti-Phospho-IRAK1(Thr387) Polyclonal Antibody |
| 别名 | IRAK (phospho T387);p-IRAK (phospho T387);IRAK1 (Phospho-Thr387);IRAK1 (Phospho-T387);IRAK1 (p-Thr387);Il1rak;Il1rak;Interleukin 1 receptor associated kinase 1;Interleukin 1 receptor associated kinase 1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 0.2μg /Test. IF 1:100-500. |
| Gene ID | 3654 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P51617 |
| 蛋白分子量 | 77kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr387 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanpigCowRabbitDogRatMouse |
| 应用 | WBIFFlow-CytIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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