Anti-Phospho-IKK alpha/beta (Ser176 + Ser180) Poly-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-Phospho-IKK alpha/beta (Ser176 + Ser180) Polyclonal Antibody
别名	IKK alpha (phospho S176 + S180);p-IKK alpha (phospho S176 + S180);I Kappa B Kinase Alpha;IKKalpha;IKK alpha;IkappaB kinase;IkB kinase alpha subunit;IKBKA;IKK 1;IKK A;IKK a kinase;IKK1;IKKA;Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells;Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit;NFKBIKA;Nuclear Factor Kappa B Inhibitor Kinase Alpha
宿主	Rabbit
稀释比例	ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.
Gene ID	1147
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O15111
蛋白分子量	85/87kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	KLH conjugated synthesised phosphopeptide derived from human IKK alpha/beta around the phosphorylation site of Ser176/Ser180
亚型	IgG
纯化方法	Affinity purification
背景资料	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
克隆类型	Polyclonal Antibody
交叉反应	HumanDogpigCowHorseChickenRatMouse
应用	ELISAIFIHC-FIHC-P
规格	50ul100ul