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产品简介
| 英文名称 | Anti-Phospho-KIT(Tyr721) Polyclonal Antibody |
| 别名 | c-Kit (phospho Y721);c-Kit (phospho Tyr721);p-c-Kit (Tyr 721);C Kit;c-Kit;CD 117;CD117;CD117 antigen;KIT;KIT_HUMAN;Mast/stem cell growth factor receptor;Mast/stem cell growth factor receptor Kit;p145 c-kit;PBT;Piebald trait protein;Proto oncogene c Kit;Proto oncogene tyrosine protein kinase Kit;Proto-oncogene c-Kit;SCF Receptor;SCFR;soluble KIT variant 1 |
| 宿主 | Rabbit |
| 稀释比例 | ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 1ug/test. IF 1:100-500. |
| Gene ID | 3815 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P10721 |
| 蛋白分子量 | 47/109kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Cell membrane |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human KIT around the phosphorylation site of Tyr721 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPigCowHorseDogRatMouse |
| 应用 | ELISAIFFlow-CytIHC-FIHC-P |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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