Anti-Phospho-RELA(Ser276) Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-Phospho-RELA(Ser276) Polyclonal Antibody
别名	NF-kB p65 (phospho S276);p-NF-kB p65 (phospho S276);RELA(phospho S276);NF kB P65;NF-kB p65;NF kB P65;NF-κBp65;p65 NF kappaB;p65 NFkB;RELA;Transcription Factor p65
宿主	Rabbit
稀释比例	ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 0.2μg /Test. ICC 1:100. IF 1:100-500.
Gene ID	5970
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q04206
蛋白分子量	59/60kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	KLH conjugated Synthesised phosphopeptide derived from human RELA around the phosphorylation site of Ser276
亚型	IgG
纯化方法	Affinity purification
背景资料	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
克隆类型	Polyclonal Antibody
交叉反应	HumanPigCowHorseDogRatMouse
应用	ELISAIFICCFlow-CytIHC-FIHC-P
规格	50ul100ul