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产品简介
| 英文名称 | Anti-YAP1 Polyclonal Antibody |
| 别名 | 65 kDa Yes associated protein;YAp 1;YAP 65;YAP;YAP2;YAP65;Yes associated protein 1 65kDa;Yes associated protein 1;Yes associated protein 2;YKI;Transcriptional coactivator YAP1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 10413 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P46937 |
| 蛋白分子量 | 54/52/48/36/50/53kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | KLH conjugated synthetic peptide derived from human YAP1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanpigCowHorseRabbitDogRatMouse |
| 应用 | WBIFIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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