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产品简介
| 英文名称 | Anti-PHD2 Polyclonal Antibody |
| 别名 | SM 20;Zinc finger MYND domain containing protein 6;C1ORF12;Chromosome 1 Open Reading Frame 12;ECYT 3;ECYT3;EGL 9 homolog of C. elegans 1;EGL nine (C.elegans) homolog 1;Egl nine homolog 1;Egl nine like protein 1;EGLN 1;EGLN1;HIF PH2;HIF Prolyl Hydroxylase 2 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 54583 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9GZT9 |
| 蛋白分子量 | 36/43/46kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | KLH conjugated synthetic peptide derived from human PHD2 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRabbitCowpigMouse |
| 应用 | WBIFIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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