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产品简介
| 英文名称 | Anti-phospho-LATS2(Ser83) Polyclonal Antibody |
| 别名 | Kinase phosphorylated during mitosis;KPM;Large tumor suppressor homolog 2;Large tumor suppressor homolog 2 Drosophila;LATS large tumor suppressor Drosophila homolog 2 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 26524 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9NRM7 |
| 蛋白分子量 | 120-150kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPigCowHorseDogRatMouse |
| 应用 | WBIFIHC-FIHC-PELISA |
| 规格 | 50ul100ul |
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1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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