Anti-HCV NS3 Polyclonal AntibodyAnt-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-HCV NS3 Polyclonal Antibody
别名	HCV-NS3;Serine protease NS3;Hepacivirin;NS3P;POLG_HCVBK;HCV NS3 transactivated protein;Hepatitis C Virus NS3;non structural polyprotein NS3;NS3;NS3P;Serine protease/NTPase/helicase. helicase NS3;NS3P;p70;NTPase;Serine protease
宿主	Rabbit
稀释比例	WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.
Gene ID	951475
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9WMX2
蛋白分子量	69kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cell membrane Cytoplasm
免疫原	KLH conjugated synthetic peptide derived from HCV-NS3
亚型	IgG
纯化方法	Affinity purification
背景资料	Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.
克隆类型	Polyclonal Antibody
交叉反应	Hepatitis C Virus
应用	WBIFIHC-FIHC-PELISA
规格	50ul100ul