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产品简介
| 英文名称 | Anti-GDF1 Polyclonal Antibody |
| 别名 | DORV;DTGA3;Embryonic growth/differentiation factor 1;GDF 1;GDF-1;GDF1;GDF1_HUMAN;Growth differentiation factor 1; |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 2657 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P27539 |
| 蛋白分子量 | 39/45kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Secreted |
| 免疫原 | A synthetic peptide of human GDF1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Growth and Differentiation Factor 1 (GDF?1) is a secreted protein in the TGF? beta superfamily (1). It is the functional equivalent of frog, zebrafish, and chick Vg1 (2, 3). Human GDF?1 is synthesized as a preproprotein that produces an approximately 44 kDa proprotein after cleavage of a 29 amino acid (aa) signal peptide. Further proteolysis at a dibasic cleavage site produces a 224 aa propeptide and a secreted 119 aa, 12?15 kDa mature peptide (4). Mature human GDF?1 shares 81% aa sequence identity with mouse and rat GDF?1. GDF?1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus (4, 5). It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord (2, 3, 6, 7). It cooperates with Nodal and GDF?3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF?1?Nodal heterodimer (3, 7, 8). The presence of Nodal is required for GDF?1 induced effects (8). GDF?1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF?CFC protein such as Cryptic or Cripto (7?9). Loss of function mutations in GDF?1 are associated with a variety of human cardiac development defects (10). |
| Public Immunogen Range | 90-140/372aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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