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产品简介
| 英文名称 | Anti-Abi1 Polyclonal Antibody |
| 别名 | Abelson interactor 1;Abi-1;Abi1;ABI1_HUMAN;Abl binding protein 4;Abl interactor 1;Abl interactor protein 1;Abl-binding protein 4;AblBP4;e3B1;Eps8 binding protein;Eps8 SH3 domain binding protein;Eps8 SH3 domain-binding protein;Eps8-binding protein;Hssh3bp1;Interactor protein AblBP4;NAP1;Nap1 binding protein;Nap1-binding protein;Nap1BP;Spectrin SH3 domain binding protein 1;Spectrin SH3 domain-binding protein 1;SSH3BP; |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 10006 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q8IZP0 |
| 蛋白分子量 | 36/43/46/49/52/54/55kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human Abi-1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. |
| Public Immunogen Range | 200-250/508aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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