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产品简介
| 英文名称 | Anti -Mki67 Polyclonal Antibody |
| 别名 | MKI67;marker of proliferation Ki-67;KIA;MIB-1;PPP1R105 |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:300-700. IF 1:600-1200. |
| Gene ID | 17345 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | E9PVX6 |
| 蛋白分子量 | 325/351kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus |
| 免疫原 | KLH conjugated Synthetic peptide corresponding to Mouse Ki67 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | MouseRat |
| 应用 | IFIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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