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产品简介
| 英文名称 | Anti-FHIT Polyclonal Antibody |
| 别名 | AP3Aase |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 2272 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P49789 |
| 蛋白分子量 | 17kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human FHIT |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+?transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. |
| Public Immunogen Range | 1-148aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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