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产品简介
| 英文名称 | Anti-phospho-PI3KCA (Tyr317) Polyclonal Antibody |
| 别名 | PIK3CA(phospho Y317); PI3 kinase p110 subunit alpha; caPI3K; MGC142161; MGC142163; p110 alpha; p110 alpha |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:5000-10000.?IHC-P 1:100-500.?IHC-F 1:100-500. IF 1:100-500. |
| Gene ID | 5290 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P42336 |
| 蛋白分子量 | 117kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Membrane |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human PI3KCA around the phosphorylation site of Tyr317 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach. |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WBIFIHC-FHC-PELISA |
| 规格 | 50ul100ul |
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