Anti-ARC Polyclonal AntibodyAnti-AR-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

英文名称	Anti-ARC Polyclonal Antibody
别名	activity regulated cytoskeleton associated protein; activity regulated gene 3.1 protein homolog; Activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein homolog; Arc; ARC/ARG3.1; ARC_HUMAN; Arg 3.1; Arg3.1;
宿主	Rabbit
稀释比例	WB 1:1000-3000.
Gene ID	23237
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q7LC44
蛋白分子量	45kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus
免疫原	A synthetic peptide ofHuman ARC
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
背景资料	Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).
Public Immunogen Range	10-60/396aa
克隆类型	Polyclonal Antibody
交叉反应	HumanPredicted:Mouse Rat
应用	WB
规格	50ul100ul