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产品简介
| 英文名称 | Anti-UBE2O Polyclonal Antibody |
| 别名 | KIAA1734;E2/E3 hybrid ubiquitin-protein ligase UBE2O;Ubiquitin carrier protein O;Ubiquitin-conjugating enzyme E2 O;Ubiquitin-conjugating enzyme E2 of 230 kDa;Ubiquitin-conjugating enzyme E2-230K;Ubiquitin-protein ligase O;(E3-independent) E2 ubiquitin-conjugating enzyme ; |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 63893 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9C0C9 |
| 蛋白分子量 | 141kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm? Nucleus |
| 免疫原 | Recombinant protein of human UBE2O |
| 亚型 | IgG |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 背景资料 | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). |
| Public Immunogen Range | 1-350aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanRatMouse |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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