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产品简介
| 英文名称 | Anti-PHACTR4 Polyclonal Antibody |
| 靶标 | PHACTR4 |
| 别名 | Phactr4;PHAR4;Phosphatase and actin regulator 4;PRO2963 |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 65979 |
| 保存 | Store at -43°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q8IZ21 |
| 蛋白分子量 | 8/76/78/79kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.26. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | A synthetic peptide of human PHACTR4 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). |
| Public Immunogen Range | 540-590/702 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPredicted:Cow,ChimpanzeeMouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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