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产品简介
| 英文名称 | Anti-ADD2 Polyclonal Antibody |
| 靶标 | ADD2 |
| 别名 | ADD2;ADDB;adducin 2 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. IHC 1:100-300. |
| Gene ID | 119 |
| 保存 | Store at -52°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P35612 |
| 蛋白分子量 | 12/32/62/64/66/73/81kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.35. |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | A synthetic peptide of human ADD2 |
| 亚型 | IgG |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 背景资料 | Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. |
| Public Immunogen Range | 465-515/726 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanPredicted:ChimpanzeeRatMouse |
| 应用 | WBIHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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