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| 英文名称 | Anti-RIT1 Polyclonal Antibody |
| 靶标 | RIT1 |
| 别名 | GTP binding protein Roc1; GTP-binding protein Rit1; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; RIT; RIT1; RIT1_HUMAN; ROC1. |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:50-200. |
| Gene ID | 6016 |
| 保存 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Swiss Prot | Q92963 |
| 蛋白分子量 | 25kDa |
| 储存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Cell membrane |
| 免疫原 | KLH conjugated synthetic peptide derived from human RIT1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins. |
| Public Immunogen Range | 141-219/219 |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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