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产品简介
| 靶标 | CNOT3 |
| 别名 | CCR4 associated factor 3; CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CNOT3; CNOT3_HUMAN; KIAA0691; LENG2; NOT3; NOT3H |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 4849 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O75175 |
| 蛋白分子量 | 82kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | A synthetic peptide of human CNOT3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Public Immunogen Range | 270-320/753aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | HumanMouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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