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产品简介
| 靶标 | TIMELESS |
| 别名 | FLJ12640;FLJ20714;hTIM;Protein timeless homolog;TIM;TIM_HUMAN;TIM1;Timeless;timeless circadian clock 1;timeless circadian clock;timeless homolog;TIMELESS1;Tof1 homolog;timeless homolog (Drosophila);hTIMTIMELESS1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 8914 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9UNS1 |
| 蛋白分子量 | 139kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Nucleus |
| 免疫原 | Recombinant protein of human TIMELESS |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098).Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725).TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725).Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214).In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214).May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197).Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588).Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465).May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). |
| Public Immunogen Range | 859-1209aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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