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产品简介
靶标 | FERMT2 |
别名 | FERMT2;KIND2;MIG2;PLEKHC1;UNC112;UNC112B;mig-2 |
宿主 | Rabbit |
预测交叉反应 | Zebrafish |
稀释比例 | WB 1:2000-5000.;IHC 1:25-100. |
Gene ID | 10979 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | Q96AC1 |
蛋白分子量 | 72/78/79kDa |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Cytoplasm Nucleus |
免疫原 | A synthetic peptide of human FERMT2 |
亚型 | IgG |
纯化方法 | Affinity purification |
背景资料 | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
Public Immunogen Range | 630-680/680aa |
克隆类型 | Polyclonal Antibody |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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