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产品简介
| 靶标 | INTS3 |
| 别名 | C1orf193; C1orf60; FLJ21919; INT 3; Int3; INT3_HUMAN; Integrator complex subunit 3; Ints3; Sensor of single-strand DNA complex subunit A; Sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A |
| 宿主 | Rabbit |
| 预测交叉反应 | Zebrafish;Fruit fly |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 65123 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q68E01 |
| 蛋白分子量 | 64/103/118kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Nucleus Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human INTS3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. |
| Public Immunogen Range | 1-349aa |
| 克隆类型 | Polyclonal Antibody |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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