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产品简介
| 靶标 | TASL |
| 别名 | TASL; TLR adapter interacting with SLC15A4 on the lysosome; Chromosome X open reading frame 21; FLJ11577; Hypothetical protein LOC80231; Uncharacterized protein CXorf21; CX021_HUMAN. |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000.;IHC 1:100-300. |
| Gene ID | 80231 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9HAI6 |
| 蛋白分子量 | 34kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human TASL |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245). |
| Public Immunogen Range | 1-302aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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