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产品简介
| 靶标 | CH25H |
| 别名 | C25H; CH25H; Cholesterol 25 hydroxylase; Cholesterol 25 monooxygenase; EC 1.14.99.38; EC=1.14.99.38; h25OH; CH25H_HUMAN |
| 宿主 | Rabbit |
| 预测交叉反应 | Zebrafish;Pig |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 9023 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O95992 |
| 蛋白分子量 | 32kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human CH25H |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. |
| Public Immunogen Range | 150-273aa |
| 克隆类型 | Polyclonal Antibody |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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