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产品简介
靶标 | IMPACT |
别名 | RWDD5;IMPACT |
宿主 | Rabbit |
预测交叉反应 | Bovine;Zebrafish;Rabbit |
稀释比例 | WB 1:1000-3000. |
Gene ID | 55364 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
Swiss Prot | Q9P2X3 |
蛋白分子量 | 23/36kDa |
储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
亚细胞定位 | Cytoplasm |
免疫原 | Recombinant protein of human IMPACT |
亚型 | IgG |
纯化方法 | Affinity purification |
背景资料 | Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. |
Public Immunogen Range | 1-321aa |
克隆类型 | Polyclonal Antibody |
应用 | WB |
规格 | 50ul100ul |
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
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