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产品简介
| 靶标 | HCFC1 |
| 别名 | CFF;HCF;HCF-1;HCF1;HFC1;MRX3;PPP1R89;VCAF |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine |
| 稀释比例 | WB 1:1000-3000.;IHC 1:100-300. |
| Gene ID | 3054 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P51610 |
| 蛋白分子量 | 2/47/209/213kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human HCFC1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. |
| Public Immunogen Range | 30-380aa |
| 克隆类型 | Polyclonal Antibody |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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