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| 靶标 | BCAR3 |
| 别名 | BCAR 3;BCAR3;BCAR3_HUMAN;Breast cancer anti estrogen resistance 3;Breast cancer anti estrogen resistance protein 3;Breast cancer anti-estrogen resistance protein 3;Breast cancer antiestrogen resistance 3;dJ1033H22.2;dJ1033H22.2 breast cancer anti estrogen resistance 3;dJ1033H22.2 breast cancer antiestrogen resistance 3;KIAA0554;Novel SH2 containing protein 2;Novel SH2-containing protein 2;NSP 2;NSP2;SH2 containing protein Nsp2;SH2 domain containing protein 3B;SH2 domain-containing protein 3B;SH2D3B |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine;Monkey |
| 稀释比例 | WB 1:5000-8000.;IHC 1:50-200. |
| Gene ID | 8412 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O75815 |
| 蛋白分子量 | 56/82/93kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cytoplasm |
| 免疫原 | Recombinant protein of human BCAR3 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110).Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110).Promotes insulin-mediated membrane ruffling (By similarity).In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031).Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity).May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity).Regulates EGF-induced DNA synthesis (PubMed:18722344).Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity).Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity).Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity).Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity).However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). |
| Public Immunogen Range | 40-390aa |
| 克隆类型 | Polyclonal Antibody |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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