Anti-BABAM2 Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

靶标	BABAM2
别名	brain and reproductive organ-expressed (TNFRSF1A modulator);BRCA1/BRCA2-containing complex subunit 45;subunit 4;BRISC and BRCA1-A complex member 2;BRCA1-A complex subunit BRE;BRCA1/BRCA2-containing complex subunit 45;Brain and reproductive organ-expressed protein;BRCC45;BRE
宿主	Rabbit
稀释比例	WB 1:1000-3000.;IHC 1:50-200.
Gene ID	9577
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9NXR7
蛋白分子量	43/44/47kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
亚细胞定位	Cytoplasm Nucleus
免疫原	Recombinant protein of human BABAM2
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
背景资料	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748).Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113).The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985).Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).
Public Immunogen Range	1-383aa
克隆类型	Polyclonal Antibody
规格	50ul100ul