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产品简介
| 靶标 | TFRC |
| 别名 | CD 71;CD71;CD71 antigen;IMD46;OTTHUMP00000208523;OTTHUMP00000208524;OTTHUMP00000208525;p90;sTfR;T9;TFR 1;TfR;TfR1;TFR1_HUMAN;TFRC;TR;Transferrin receptor (p90 CD71);Transferrin receptor protein 1, serum form;Trfr |
| 宿主 | Rabbit |
| 预测交叉反应 | Orangutan;Horse;Cat;Dog;Pig;Chicken |
| 稀释比例 | WB 1:1000-3000.;IHC 1:100-300. |
| Gene ID | 7037 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P02786 |
| 蛋白分子量 | 85kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cell membrane Secreted |
| 免疫原 | Recombinant protein of human TFRC |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738).When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738).When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). |
| Public Immunogen Range | 101-450aa |
| 克隆类型 | Polyclonal Antibody |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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