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产品简介
| 靶标 | NCK1 |
| 别名 | Cytoplasmic protein NCK1;Melanoma Nck protein;MGC12668;NCK 1;NCK adaptor protein 1;NCK alpha;NCK;NCK tyrosine kinase;Nck-1;NCK1;NCK1_HUMAN;NCKalpha;Non catalytic region of tyrosine kinase;SH2/SH3 adaptor protein NCK alpha;SH2/SH3 adaptor protein NCK-alpha |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 4690 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P16333 |
| 蛋白分子量 | 36/43kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Nucleus Cytoplasm Cell membrane |
| 免疫原 | Recombinant protein of human NCK1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. |
| Public Immunogen Range | 1-349aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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