Anti-BRCA1 Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

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产品简介

靶标	BRCA1
别名	BRCA 1;BRCA1;BRCA1 DNA repair associated;BRCA1/BRCA2 containing complex subunit 1;BRCA1/BRCA2-containing complex, subunit 1;BRCA1_HUMAN;BRCAI;BRCC 1;BRCC1;Breast and ovarian cancer susceptibility protein 1;Breast Cancer 1;Breast Cancer 1 Early Onset;Breast cancer type 1 susceptibility protein;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;Protein phosphatase 1 regulatory subunit 53;PSCP;RING finger protein 53;RNF53
宿主	Rabbit
预测交叉反应	Bovine;A.thaliana;Chimpanzee;Dog
稀释比例	IHC 1:50-200.
Gene ID	672
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P38398
蛋白分子量	7/78/81/85/202/206/208/210kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
亚细胞定位	Cytoplasm Nucleus Cell membrane
免疫原	Recombinant protein of human BRCA1
亚型	IgG
纯化方法	Affinity purification
背景资料	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748).It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172).Regulates centrosomal microtubule nucleation (PubMed:18056443).Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748).Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698).Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211).Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604).Acts as a transcriptional activator (PubMed:20160719).
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
交叉反应	Human;Mouse;Rat
应用	IHC
规格	50ul100ul