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产品简介
| 靶标 | MMP13 |
| 别名 | CLG 3;CLG3;Collagenase 3;Collagenase3;MANDP1;Matrix metallopeptidase 13 (collagenase 3);Matrix Metalloproteinase 13;Matrix metalloproteinase-13;MMP 13;MMP-13;Mmp13;MMP13_HUMAN;EC 3.4.24.22;EC 3.4.24.24;EC 3.4.24.35;EC 3.4.24.65;EC 3.4.24.7 |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine;Horse;Rabbit |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 4322 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P45452 |
| 蛋白分子量 | 54kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Secreted |
| 免疫原 | Recombinant protein of human MMP13 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. |
| Public Immunogen Range | 1-350aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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