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产品简介
| 靶标 | KISS1R |
| 别名 | AXOR12;CPPB1;GPR54;HH8;HOT7T175;KISS-1R;AXOR 12;AXOR12;G protein coupled receptor 54;G-protein coupled receptor 54;G-protein coupled receptor OT7T175;GPCR 54;GPCR54;GPR 54;GPR54;hOT7T175;Hypogonadotropin 1;Hypogonadotropin-1;Hypogonadotropin1;KISS 1 receptor;KISS 1R;KiSS-1 receptor;KiSS-1R;KISS1 receptor;Kiss1r;Kisspeptins receptor;KISSR_HUMAN;Metastin receptor;OT7T175 |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 84634 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q969F8 |
| 蛋白分子量 | 43kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | A synthetic peptide of human KISS1R |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Public Immunogen Range | 255-305/398aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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