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产品简介
| 靶标 | PGAP6 |
| 别名 | TMEM6 ;PGAP6 ;TMEM8A ;M83 ;Post-GPI attachment to proteins factor 6 ;GPI processing phospholipase A2 ;GPI-PLA2 ;Protein M83 ;Transmembrane protein 6 ;Transmembrane protein 8 ;Transmembrane protein 8A |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine ;Zebrafish |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 58986 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q9HCN3 |
| 蛋白分子量 | 85kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cell membrane Cytoplasm |
| 免疫原 | Recombinant protein of human PGAP6 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). |
| Public Immunogen Range | 36-380aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human ;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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