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产品简介
| 靶标 | TNPO2 |
| 别名 | FLJ12155, IPO3, KPNB2B, Importin 3 ; IPO3 ; Karyopherin beta 2b, transportin ; KPNB2B ; TNPO2 ; Transportin 2 (importin 3, karyopherin beta 2b) ; Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b ; Transportin 2 ; TRN2 |
| 宿主 | Rabbit |
| 稀释比例 | IHC 1:50-200. |
| Gene ID | 30000 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | O14787 |
| 蛋白分子量 | 100/101kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human TNPO2 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). |
| Public Immunogen Range | 1-350aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human ;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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