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产品简介
| 靶标 | PSME4 |
| 别名 | PA200 ;KIAA0077 ; Proteasome Activator 200 kDa ; Proteasome activator complex subunit 4 ; Proteasome activator PA200 ; PSME 4 ; psme4 ; PSME4_HUMAN |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine ;Zebrafish |
| 稀释比例 | WB 1:1000-3000. ;IHC 1:50-200. |
| Gene ID | 23198 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | Q14997 |
| 蛋白分子量 | 25/114/140/211kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human PSME4 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. |
| Public Immunogen Range | 1-20216aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human ;Mouse ;Rat |
| 应用 | WB IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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