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产品简介
| 靶标 | HLA-B |
| 别名 | AS ; B-4901 ; B-7 alpha chain ; HC class I antigen SHCHA ; HLA class I histocompatibility antigen ; HLA class I histocompatibility antigen, B alpha chain ; HLA-B ; HLA-B histocompatibility type ; HLAB ; leukocyte antigen class I-B ; major histocompatibility complex, class I, B ; MHC class 1 antigen ; MHC class I antigen B*7 ; MHC class I antigen HLA-B alpha chain ; MHC class I antigen HLA-B heavy chain ; MHC Class I HLA heavy chain ; MHC class I molecule ; MHC HLA-B cell surface glycoprotein ; MHC HLA-B transmembrane glycoprotein ; SPDA1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:1000-3000. |
| Gene ID | 3106 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P01889 |
| 蛋白分子量 | 40kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Cell membrane |
| 免疫原 | Recombinant protein of human HLA-B |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. |
| Public Immunogen Range | 1-363aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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