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产品简介
| 靶标 | ATF1 |
| 别名 | EWS-ATF1 ;FUS/ATF-1 ;TREB36 ; Activating transcription factor 1 ; ATF 1 ; atf1 ; ATF1 EWS fusion gene ; ATF1 FUS fusion gene ; ATF1_HUMAN ; cAMP dependent transcription factor 1 ; cAMP-dependent transcription factor ATF-1 ; Cyclic AMP dependent transcription factor ATF 1 ; Cyclic AMP dependent transcription factor ATF1 ; Cyclic AMP-dependent transcription factor ATF-1 ; EWS AFT1 ; FUS ATF 1 ; FUS/ATF 1 ; Protein TREB36 ; RNA binding protein activating transcription factor 1 fusion protein ; TREB 36 ; TREB36 ; TREB36 protein |
| 宿主 | Rabbit |
| 预测交叉反应 | Bovine |
| 稀释比例 | IHC 1:100-300. |
| Gene ID | 466 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P18846 |
| 蛋白分子量 | 15/29kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. |
| 亚细胞定位 | Nucleus |
| 免疫原 | Recombinant protein of human ATF1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. |
| Public Immunogen Range | 1-272aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human ;Mouse |
| 应用 | IHC |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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