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产品简介
| 靶标 | ErbB2 |
| 别名 | CD340;HER-2;HER2;NEU;NGL |
| 宿主 | Mouse |
| 稀释比例 | WB 1:2000-4000; IHC 1:200; ICC 1:200. |
| Gene ID | 2064 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P04626 |
| 蛋白分子量 | 63/71/97/135/137/138kDa |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm Membrane, Nucleus |
| 免疫原 | Synthetic Peptide of HER2 |
| 亚型 | IgG1 |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| 克隆类型 | Monoclonal Antibody |
| 规格 | 50ul100ul |
注意：
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