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产品简介
| 靶标 | Phospho-AKT1-S473 |
| 别名 | AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA;AKT1 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| Gene ID | 207 |
| 保存 | Store at -20℃. Avoid freeze / thaw cycles. |
| Swiss Prot | P31749 |
| 蛋白分子量 | 48/55kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| 亚细胞定位 | Cell membrane Cytoplasm Nucleus |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S473 of human AKT1 |
| 亚型 | IgG |
| 纯化方法 | Affinity purification |
| 背景资料 | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| 克隆类型 | Polyclonal Antibody |
| 规格 | 50ul100ul |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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